Today we get back to Jack, the Belgian shepherd Malinois, eight years old, diagnosed with ‘idiopathic epilepsy’, a form of epilepsy which involves a group of strong gene-based epileptic disorders .
“The first seizure occurred in April, 2016 – Fernando tells us, who found Jack in a kennel in Spain – and he started to take an antiepileptic when a second seizure occurred. We returned to Bilboa where one of the best European neurologists for dogs, conducted verification tests on brain tumours, infections and thyroid diseases”. The test results were negative, excluding other pathologies.
For the treatment of the disease the veterinarian suggested the use of a second drug besides the one already administered, which, unfortunately, presented unpleasant side effects. Jack had a series of skin rashes.
Fernando decided to stop administering the second drug, which he substituted with Premium Hemp Extract 10%, starting with a very low dosage.
“After a month, Jack seemed much healthier and happier, even though the seizures appeared every two and a half weeks again".
"Jack started to seem less stressed with a dosage of 2 mg a day, taken at breakfast and dinner. My objective is to find the correct CBD dosage for him”.
One year later, we met Fernando again, a story of coexistence between Jack and the disease and the knowledge of CBD.
“We started to take CBD in October 2017 and after two weeks we said ‘maybe it’s working’, an entire month passed, two months, three months, six months…incredible... we started to reduce the dosage of the antiepileptic drug, because CBD seemed to be working”.
Fernando tells us how Jack stopped having seizures completely up to last August, which made him decide to reduce the traditional drug to 50 mg a day, which is 20% of the initial dosage. CBD on the other hand was equal to about 60 mg a day.
Fernando thus decides to lower the dosage further to 25 mg a day, after ten days Jack has a seizure, from which he recovered fast without the use of the emergency drugs.
“This experience taught us that the level of the medical drug had to be stabilized at the previous dosage of 50 mg daily. We thus found a point of stability, Jack is taking 20% of the initial dosage with 60 mg CBD”.
CBD, how Jack is doing today
“I’m happy about the progress Jack made – Fernando tells us – he started doing sport with me again and soon he will have his eighth birthday. We are much more serene and conscious of the fact that we’ve got epilepsy under control. In the last year he only had one seizure which was however provoked by us when we decreased the dosage of the medical drug further”.
“We also tried CBD for Pets, the results are the same, however, changing the concentration of CBD, the dosage and the use of the products vary”.
Vertebrate animals have an endocannabinoid system equal to that of human beings, which acts on a wide range of biological processes inside the organism.
This means that cannabidiol acts on animals in a very similar way to the way it interacts with human beings.
A standard dosage to start from exists, based on weight, which will then be modulated according to the pathology of the patient.
Experience and scientific literature on the Topic do not underline cases with particular side effects, however, it is always recommended to consult a veterinarian doctor.
What is the purpose of the endocannabinoid system
The endocannabinoid system is involved in the control of appetite as well as in many other physiological functions correlated with stress response and the maintenance of homeostasis.
Endocannabinoids have neuro-protectant properties, are able to regulate motor activity and memory.
The Endocannabinoid System is involved in the modulation of the immune, anti-inflammatory, endocrine responses and exerts an anti-proliferative action as well.
Endocannabinoids also effect the cardiovascular and respiratory systems, controlling heart rate, reducing arterial pressure and favouring bronchial dilatation.
The endocannabinoid system
The receptors of the endocannabinoid system are CB1 and CB2.
CB1 is a membrane receptor situated in the central nervous system in two areas, controlling dietary behaviour: the mesolimbic area, related to the pleasure of consuming tasty food, alcohol, nicotine, and drugs, and the hypothalamic area, related to the production of molecules regulating food intake.
CB1 receptors are also present in the organs controlling metabolism, like the gastro-intestinal tract, the liver, the endocrine pancreas, adipose and musculoskeletal tissue.
CB2 on the other hand, is a receptor involved in bone metabolism and has the capacity to modulate the immune response.