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Neurological dysfunctions are the most severe and persistent consequences of traumatic brain injury (TBI).

Many are the scientific investigations demonstrating how a brain injury following a trauma is associated, in certain cases, with the onset of chronic pain or recurrent states of anxiety or depression. At the moment no effective therapeutic options are available for individuals finding themselves in this condition.

Due to the growing interest from the medical community towards the use of cannabidiol (CBD) with regard to its indirect action on chronic pain and on a wide range of other pathologies, researchers of the SUN, Second University of Naples, wanted to bring clarity on the possibilities of application of cannabidiol in alleviating the symptoms caused by a traumatic brain injury.

According to the conclusions of the study – conducted on laboratory mice and published in Frontiers in Pharmacology – the treatment with Enecta  CBD oil in a 10% concentration gives beneficial effects on behavioural dysfunctions associated to brain trauma.

Moreover, with the concentration of cannabidiol (CBD) used  in the study, no negative modifications in behaviour or in locomotion of the mice were detected.

The research team used mice presenting brain traumas and which had developed chronic pain and at the same time anxious or aggressive behaviour, followed by altered social interaction with fellow mice.

This behaviour was related to specific changes in the release of neurotransmitters at the cortical level. Cannabidiol (CBD), administered orally, cancelled the alterations in behaviour and partially normalized the ongoing biochemical changes at cortical the level.

A prolonged treatment with Enecta Premium Hemp Extract 10% demonstrated its effectiveness in treating a post -TBI condition in the mice, without any side effects.

As already demonstrated in previous studies, the mice presented an abnormal response to being touched. This phenomenon is called allodynia: a pain impulse felt after an innocuous stimulus.

The daily treatment with cannabidiol reduced this kind of response, making it completely disappear after 30 days.

There is still a lot of research to be done and this study is part of a pathway  - strongly desired by Enecta - aimed at clarifying the prospectives and the actual margins of use of cannabidiol (CBD).

The study carried out by the male and female researchers of the University of Naples is based on an animal model and further investigations need to be conducted in order to obtain ever more answers to the queries presented more and more each day on the topic of cannabis.

For the moment, also this study is giving suggestions about how CBD can be considered a new approach in the management of neuropsychiatric disorders derived from brain trauma.