Amongst the more than 80 cannabinoids identified thus far and contained in cannabis, we can find CBG, cannabigerol, a non-psychotropic cannabinoid of which we introduced the first concepts in the past days in the articles of our Blog.
Why is CBG important?
Cannabigerol can be considered the “stem cell” of many chemical substances present in Cannabis. Due to the action of some enzymes, CBG is converted to other types of Cannabinoids, hence proving to be important in the therapeutic use of Cannabis connected to its characteristics.
Bonni Goldstein, Medical director of Canna-Centers, has stated in the past how CBG inhibits the absorption of a chemical substance called GABA, with the same mechanisms of cannabinoids.
What does this mean?
It means that CBG gives muscle relaxation and contrasts anxiety states, in the same way as CBD does.
The Italian study on CBG
A study carried out by researchers from the department of Pharmacy of the University of Naples, Federico II, in collaboration with medical professionals of the Diagnostic department of the Pellegrini Hospital in Naples and researchers of the CNR in Pozzuoli, has demonstrated the action of CBG in a case of intestinal inflammation and arrived to the conclusion that “cannabigerol is a new therapeutic opportunity for those suffering from the above mentioned disorder”.
Certainly, additional studies will be necessary to determine what effectively is the therapeutic potential of CBG; we can however state that besides CBD and THC, there are other molecules capable of offering a support in the therapeutic area.
The 5 things to know about CBG
1 - Anti-nausea and anti-emeticPreclinical studies have demonstrated how CBG can have anti-nausea and antiemetic effects.
2 - Bladder dysfunctionsCBG proves to be the most effective cannabinoid in the treatment of dysfunctions of the bladder.
3 - Inflammatory intestinal diseases
CBG possesses strong beneficial anti-inflammatory and analgesic properties for inflammatory intestinal diseases, like Crohn’s Disease, of which we have already talked, underlining also the contribution of CBD.
4 - Antidepressant
Some researchers state how CBG has got antidepressant properties with potentially painkilling effects as well.
5 - Psoriasis
CBG helps to contract this type of pathology, a topic we’ve already discussed in relation to the effectiveness that also CBD proves to have in this context, read our testimony.
Which are the differences between CBG and CBD?
CBD and CBG are two different cannabinoids contained inside cannabis plants; they have very different chemical structures and concentrations.
Unlike CBD, CBG is a cannabinoid which carries out its function as a basis for many other compounds produced by the plants during their growth. CBG and CBD are non-psychotropic compounds, CBG increases the production of anandamide, the main endogenous cannabinoids present in our body.
Anandamide helps to regulate sleep, appetite and memory, acting directly on the CB1 and CB2 receptors.
CBD on the other hand, reduces the access to anandamide by the fatty acids, acting as transport molecules.
CBD doesn’t interact directly with the CB1 or CB2 receptors, which are mainly present in our brain and in our central nervous system. CBG, instead, acts on the receptors as a partial agonist. But the intensity of these effects is not at all comparable to those of THC.